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Institute of Pharmacology and Toxicology Medical Faculty O. Guericke University Leipziger Str. Mitragyna speciosa and its extracts are named kratom (dried leaves extract). It contains several alkaloids and is used in traditional medicine to alleviate musculoskeletal pain hypertension coughing diarrhea and as an opiate substitute for addicts. Abuse and addiction to kratom is described and kratom has attracted increasing interest in Western countries. Individual effects of kratom on opioidergic adrenergic serotonergic and dopaminergic receptors are known but not all of the effects have been explained.