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Jiang et al 2006; Li et al 2001; Cande et al 2001) (refer to fig. As discussed by Jiang et al (2006) evidence also shows that lysosomal pathways may lead to different cell death depending on the type of cells and stimuli. Roberg et al 2002; cbs denver kratom Guicciardi et al 2000). The release of lysosomal poteases such as cysteine cathepsin B and L and aspartyl cathepsin D may lead to necrosis apoptosis or necrosis-like cell death (Katunuma et al 2004; Brunk et al kratom withdrawal restlessness 1997).
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